Inflammatory cap polyp

Topic Completed: 1 August 2011

Minor changes: 18 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Inflammatory Cap polyp

Shilpa Jain, M.D.
Page views in 2020: 4,967
Page views in 2021 to date: 5,220
Cite this page: Jain S. Inflammatory cap polyp. website. Accessed October 28th, 2021.
Definition / general
  • First described in an abstract in 1985 (Br J Surg 1985; 72 (Suppl) S133)
  • Rare
  • Etiology unknown, but may be associated with mucosal prolapse (Gut 1993;34:562)
  • Often presents with mucoid or bloody diarrhea and hypoproteinemia
  • Endoscopy: multiple sessile rectosigmoid polyps with adherent white flecks with normal intervening mucosa (Endoscopy 2001;33:262)
Gross description
  • Multiple, distinctive, inflammatory rectosigmoid polyps
Gross images

Images hosted on other servers:

Multiple colonic polyps

Microscopic (histologic) description
  • Inflamed mucosa with tortuous, elongated crypts attenuated towards the mucosal surface with abundant inflammation in the lamina propria and characteristic "cap" of inflamed and ulcerated granulation tissue on the mucosal surface
Microscopic (histologic) images

Contributed by Andrea L. Wiens, D.O. and Janet E. Roepke, M.D., Ph.D.

Inflammatory polyp of colon secondary to mucosal prolapse

Differential diagnosis
  • Amebic colitis
  • Antibiotic associated colitis
  • Inflammatory bowel disease
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