Mesenchymal tumors


Topic Completed: 1 September 2016

Minor changes: 1 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Fibromatosis [title] colon

Raul S. Gonzalez, M.D.
Page views in 2020: 2,580
Page views in 2021 to date: 2,036
Cite this page: Gonzalez R. Fibromatosis. website. Accessed September 20th, 2021.
Definition / general
  • Colon wall is an uncommon location for aggressive (desmoid) fibromatosis
  • See also Soft tissue topic
Essential features
  • Locally aggressive mesenchymal proliferation more commonly arising in the mesentery or retroperitoneum
  • Associated with Gardner syndrome
  • Aggressive fibromatosis and desmoid tumor are synonyms
Clinical features
Radiology description
Case reports
  • Surgical excision, radiation therapy, possibly chemotherapy
Clinical images

Images hosted on other servers:

Colonic desmoid on PET / CT

Gross description
  • Firm, tan, homogenous
  • Usually large (up to 25 cm) with infiltrative borders
Microscopic (histologic) description
  • Broad, sweeping fascicles of bland spindle cells with low mitotic activity, bland nuclear features, finely collagenous stroma with evenly spaced blood vessels and infiltrative borders
  • Tumor may extend through colonic wall up to muscularis propria
  • No necrosis, no hemorrhage, no pleomorphism, no myxoid degeneration, no epithelioid cells, no foam cells
Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D.

Various images

Positive stains
Negative stains
Electron microscopy description
  • Myofibroblastic / fibroblastic differentiation
Molecular / cytogenetics description
Differential diagnosis
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