Gardner syndrome

Topic Completed: 1 April 2016

Minor changes: 1 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Gardner syndrome [title] colon tumor

Jennifer Findeis-Hosey, M.D.
Raul S. Gonzalez, M.D.
Page views in 2020: 2,009
Page views in 2021 to date: 79
Cite this page: Findeis-Hosey J, Gonzalez R. Gardner syndrome. website. Accessed January 17th, 2021.
Definition / general
Essential features
  • Features of FAP and extraintestinal lesions, including desmoid tumors, bone osteomas and fibromas
  • Due to a mutation in the APC tumor suppressor gene
  • Rarely also called Plenk-Gardner syndrome
  • Incidence of 1 per million in US
  • Colonic adenomatous polyps plus extraintestinal features, including multiple osteomas (skull, mandible and long bones), epidermal cysts, desmoid fibromatosis (10%, usually arise after intra-abdominal surgery, aggressive and may cause death), fibromas, lipomas, impacted and supernumerary teeth, dental cysts and congenital hypertrophy of retinal pigment epithelium
Radiology images

Images hosted on other servers:

Abdominal CT showing
desmoid fibromatosis
in Gardner syndrome

Case reports
Gross images

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Innumerable colon polyps from Gardner patient

Desmoid fibromatosis

Additional references
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