Colon (tumor & nontumor)

Topic Completed: 1 April 2015

Minor changes: 31 July 2020

Copyright: 2002-2019,, Inc.

PubMed Search: "Hepatoid carcinoma" colon

Raul S. Gonzalez, M.D.
Page views in 2019: 801
Page views in 2020 to date: 628
Cite this page: Gonzalez R. Hepatoid. website. Accessed August 3rd, 2020.
Definition / general
  • Rare, aggressive subtype of adenocarcinoma that morphologically resembles hepatocellular carcinoma and produces alpha fetoprotein
  • Originally termed "alpha fetoprotein producing tumor"
  • More common in men
  • Fewer than 20 colonic cases reported
Clinical features
Case reports
Microscopic (histologic) description
  • Resembles hepatocellular carcinoma, with trabecular or solid pattern of large polygonal cells with abundant eosinophilic or clear cytoplasm
  • Component of traditional adenocarcinoma also often present
  • Lymphovascular invasion is common (Histopathology 1997 Jul;31:47)
Microscopic (histologic) images

Images hosted on other servers:

Collision with liposarcoma

Associated with ulcerative colitis

Gastric tumor: H&E, AFP+ Hep Par 1- glypican3+

Differential diagnosis
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