Mesenchymal tumors


Topic Completed: 29 January 2021

Minor changes: 29 January 2021

Copyright: 2003-2021,, Inc.

PubMed search: lipoma [title] colon

Raul S. Gonzalez, M.D.
Page views in 2020: 3,476
Page views in 2021 to date: 4,190
Cite this page: Gonzalez RS. Lipoma. website. Accessed October 28th, 2021.
Definition / general
  • Benign colonic neoplasm composed of mature adipose tissue
Essential features
  • Most common submucosal mesenchymal lesion of colon
  • Typically small and benign but can cause symptoms if large
  • Usually submucosal in right colon
Clinical features
Case reports
Gross description
  • Soft, yellow cut surface
  • Size can vary; large lesions may have overlying ulceration
Gross images

Images hosted on other servers:

Large pedunculated submucosal tumor

Cut section of tumor

Microscopic (histologic) description
Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D.

Intramucosal lipoma

Images hosted on other servers:

Lipoma with overlying sessile serrated adenoma

Sample pathology report
  • Ascending colon, polypectomy:
    • Colonic mucosa with focus of benign submucosal fat, compatible with lipoma
  • Descending colon, polypectomy:
    • Intramucosal lipoma (see comment)
    • Comment: Intramucosal lipomas have been associated with Cowden syndrome in some patients. Additional clinical evaluation may be warranted.
Differential diagnosis
Board review style question #1
Benign fatty lesions of the colon usually arise in what layer of the wall?

  1. Lamina propria
  2. Muscularis mucosae
  3. Muscularis propria
  4. Submucosa
  5. Subserosa
Board review style answer #1
D. Submucosa

Comment here

Reference: Lipoma
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