Colon tumor
Mesenchymal tumors

Topic Completed: 1 April 2017

Revised: 9 July 2019

Copyright: 2003-2017,, Inc.

PubMed search: colonic lipomatosis

Raul S. Gonzalez, M.D.
Page views in 2019: 2,654
Page views in 2020 to date: 129
Cite this page: Gonzalez R. Lipomatosis. website. Accessed January 25th, 2020.
Definition / general
  • Development of multiple benign lipomas throughout the colon
Essential features
  • Multiple submucosal lipomas arise in colon, usually in young patients
  • Rare process that may cause intestinal obstruction
  • Sometimes termed lipohyperplasia
  • Fewer than two dozen cases reported
Clinical features
Case reports
Gross description
  • Colon may demonstrate polypoid masses of fat covered by normal mucosa or diffuse wall thickening with grey / yellow submucosa
Microscopic (histologic) description
  • Multifocal or diffuse fatty infiltration of the colonic submucosa, with no evidence of malignancy
Microscopic (histologic) images

Images hosted on other servers:

Lipomatosis (low power)

Lipomatosis (high power)

Differential diagnosis
Board review question #1
A patient with diarrhea undergoes colonoscopy and a small whitish plaque is observed and biopsied. Microscopically, the tissue showed a focal region of rounded, empty, vacuolar spaces of varying sizes in the mucosa, infiltrating around the colonic crypts. The visible submucosa is unremarkable. Which of the following is true?

  1. Full body workup for metastatic liposarcoma should be undertaken
  2. This finding is artifactual and can be safely ignored
  3. This patient likely has a glycogen storage disorder
  4. This patient likely has familial multiple lipomatosis
  5. This patient likely has neurofibromatosis
Board review answer #1
B. The finding is mucosal pseudolipomatosis

Reference: Colon tumor - Lipomatosis

Comment here
Back to top