Colon
Other tumors
Mantle cell lymphoma


Topic Completed: 1 February 2012

Minor changes: 25 February 2021

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PubMed Search: Mantle cell lymphoma colon


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Cite this page: Singh C. Mantle cell lymphoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/colontumormcl.html. Accessed April 19th, 2021.
Definition / general
Case reports
Gross description
  • Nodular, sessile or polypoid lesions, widely spaced and confluent studded or cobblestone appearance
  • Each polyp 2 mm to 2 cm
  • May be dominant tumor mass in ileocecum
  • Endoscopically normal mucosa may have small tumor infiltrates also
Gross images

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Lymphomatoid polyposis

Microscopic (histologic) description
  • Mantle cells (small lymphocytes with pale cytoplasm and cleaved nuclei), often invasion of submucosa, proliferation around germinal centers and sparing of mucosa
  • Late epithelial invasion and ulceration
  • Note: may also be minute lymphoid infiltrates in known mantle cell patients
Microscopic (histologic) images

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80 year old woman

Positive stains
Negative stains
Differential diagnosis
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