Squamous cell carcinoma

Topic Completed: 12 February 2021

Minor changes: 17 February 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Squamous cell carcinoma[TI] colon[TI]

Raul S. Gonzalez, M.D.
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Cite this page: Gonzalez RS. Squamous cell carcinoma. website. Accessed October 21st, 2021.
Definition / general
Essential features
Clinical features
Prognostic factors
Case reports
Gross images

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Rectal squamous cell carcinoma

Microscopic (histologic) description
  • Similar to squamous cell carcinoma in other organs (polygonal eosinophilic cells with intercellular bridges and keratin formation)
  • Can be poorly differentiated
  • May be basaloid or acantholytic
Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D.
Squamous cell carcinoma Squamous cell carcinoma

Squamous cell carcinoma

Positive stains
Sample pathology report
  • Ascending colon, resection:
    • Squamous cell carcinoma of the colon (see synoptic report and comment)
    • Comment: An immunohistochemical stain for p40 is diffusely positive.
Differential diagnosis
Board review style question #1

    Colonic squamous cell carcinoma can arise in the setting of

  1. Colonic epidermal inclusion cysts
  2. Diverticulitis
  3. HPV infection
  4. Schistosomiasis
Board review style answer #1
D. Schistosomiasis

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Reference: Squamous cell carcinoma
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