Colon nontumor
Nonneoplastic, noncongenital lesions
Vasculitis - intramural phlebitis (enterocolic lymphocytic phlebitis)

Topic Completed: 1 November 2013

Minor changes: 14 December 2019

Copyright: (c) 2003-2019,, Inc.

PubMed Search: enterocolic lymphocytic phlebitis

Raul S. Gonzalez, M.D.
Page views in 2019: 277
Page views in 2020 to date: 183
Cite this page: Gonzalez, R.S. Vasculitis - intramural phlebitis (enterocolic lymphocytic phlebitis). website. Accessed May 30th, 2020.
Definition / general
  • Localized, predominantly lymphocytic infiltration of intramural tributaries of mesenteric veins
  • Variously called enterocolic, lymphocytic, granulomatous or necrotizing phlebitis
  • "Mesenteric inflammatory veno-occlusive disease" no longer in favor
  • Typically ileocecal
  • Some cases associated with use of hydroxyethylrutoside; others of unknown origin
Clinical features
  • Abdominal pain (due to ischemia; Am J Surg Pathol 1989;13:303) or mass (due to edema) in middle age or elderly patients
  • Patients do not have systemic vasculitis
Case reports
Gross description
  • Bowel may appear edematous or ischemic
Microscopic (histologic) description
  • Circumferential lymphocytic phlebitis affecting all layers of bowel wall, with numerous associated thrombi
  • Arterioles and arteries not affected
  • Necrosis and granuloma formation may be present
  • Background mural edema, hemorrhage and necrosis
Differential diagnosis
  • Phlebitis secondary to systemic vasculitides
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