External ear tumors - malignant

Ceruminous adenocarcinoma

Topic Completed: 1 January 2014

Minor changes: 14 December 2020

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PubMed Search: ceruminous adenocarcinoma

Nat Pernick, M.D.
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Cite this page: Pernick N. Ceruminous adenocarcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/earceruminalglandadenocarcinoma.html. Accessed December 8th, 2021.
Definition / general
  • Usually men, ages 30 - 59 years but wide age range
  • Associated with local pain
  • Tends to recur locally; only rarely metastasizes to regional lymph nodes and lung
  • Adenoid cystic carcinoma subtypes (Eur Arch Otorhinolaryngol 1993;250:240) usually have relatively good 5 year survival, but poor 10 and 20 year survival
  • En bloc resection
  • More radical surgery if middle ear or temporal bone involvement
  • Radiation therapy
Case reports
Microscopic (histologic) description
  • Loss of glandular double cell layer as only luminal epithelial cells are present
  • Pleomorphism, nuclear anaplasia, mitotic activity and invasive growth are evident except in well differentiated tumors which may resemble adenomas except for invasive growth
  • Variants include adenoid cystic carcinoma and mucoepidermoid carcinoma
Differential diagnosis
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