Congenital anomalies

Heterotopia / choristoma

Last author update: 1 October 2013
Last staff update: 14 December 2020

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PubMed Search: Heterotopia choristoma [title] ear

Related Topics: Lipochoristoma

Nat Pernick, M.D.
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Cite this page: Pernick N. Heterotopia / choristoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/earheterotopia.html. Accessed June 16th, 2024.
Definition / general
  • WHO classification includes salivary gland choristoma and glial choristoma
  • Heterotopia: mass of tissue normal to the site in abnormal location
  • Choristoma: mass of tissue foreign to the site
  • Hamartoma: mass of tissue normal to site in haphazard arrangement
  • Middle ear choristomas include salivary gland tissue and neuroglial tissue
  • Salivary gland choristomas usually occur in women, associated with facial nerve and ossicle anomalies, suggesting a second branchial arch developmental anomaly; have mucinous and serous elements similar to submandibular and sublingual glands
  • Neuroglial choristomas are often actually an acquired encephalocele with herniation of brain into middle ear and mastoid; treatment is surgical, although tissue may adhere to facial nerve; determine relationship to CNS structures at operation or radiographically, not by histology (Laryngoscope 2000;110:1731, Ann Diagn Pathol 2004;8:252)
  • Cartilaginous choristoma of external ear canal: may be relatively common (Otolaryngol Head Neck Surg 2005;133:786)
Case reports
Radiology images

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Mass-like lesion
with soft tissue
density occupying
the middle ear
Microscopic (histologic) images

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Mature disorganized
glial tissue and
fibrovascular elements
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GFAP+, S100+

Additional references
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