Inflammatory / infectious / autoimmune / systemic disorders


Last author update: 1 October 2013
Last staff update: 14 December 2020

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PubMed Search: Myospherulosis ear

Nat Pernick, M.D.
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Cite this page: Pernick N. Myospherulosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/earmyospherulosis.html. Accessed June 3rd, 2023.
Definition / general
  • Iatrogenic due to petrolatum based ointments
  • Usually nasal cavity and paranasal sinuses; occasionally affects middle ear
  • History of recent surgery with packing of area (Am J Clin Pathol 1977;67:118)
  • Associated with postoperative adhesions after sinus surgery (Laryngoscope 2003;113:1123)
Case reports
  • Symptomatic
Gross description
  • Ointment like material within granulation tissue
Microscopic (histologic) description
  • Pseudocysts within fibrous tissue with lymphocytes, histiocytes, giant cells and plasma cells
  • Pseudocysts contain "parent bodies" containing numerous spherules
Negative stains
  • GMS for fungi
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