Topic Completed: 1 September 2012

Minor changes: 21 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: CMV cytomegalovirus esophagus[TIAB]

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. CMV. website. Accessed October 25th, 2021.
Definition / general
  • Histology is necessary to confirm diagnosis; repeat biopsy may be necessary
Case reports
Gross description
Microscopic (histologic) description
  • Virus present in enlarged endothelium and stromal cells at ulcer base
  • Basophilic cytoplasm often has coarse intracytoplasmic granules
  • Prominent intranuclear basophilic inclusions surrounded by clear halo
  • Macrophage aggregates in perivascular distribution are somewhat specific for CMV or HSV (Hum Pathol 1997;28:375); features are less obvious in patients receiving antiviral therapy
  • Inclusions are generally numerous but may be atypical in HIV patients (Hum Pathol 1992;23:1019)
Microscopic (histologic) images

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CMV and leishmaniasis

Positive stains
  • CMV immunostain or in situ hybridization
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