Adenosquamous carcinoma

Topic Completed: 1 September 2013

Minor changes: 15 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Adenosquamous carcinoma esophagus

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Adenosquamous carcinoma. website. Accessed October 22nd, 2021.
Definition / general
  • Carcinoma that contains mixed elements of adenocarcinoma and squamous cell carcinoma, which remain clearly distinguishable within the tumor (WHO)
  • Most authorities reserve term for tumors with substantial elements of each component as minor divergent differentiation is not uncommon
Clinical features
  • Endoscopic biopsy
Case reports
  • Resection if possible
  • Usually multimodality treatment
Microscopic (histologic) description
  • Admixed squamous cell carcinoma and adenocarcinoma
Microscopic (histologic) images

AFIP images

Adenosquamous carcinoma

Positive stains
  • Rarely necessary
  • CD44 (in squamous areas), Alcian blue pH 2.5 in glandular component
Differential diagnosis
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