Other nonneoplastic

Atypical regenerative hyperplasia

Topic Completed: 1 November 2012

Minor changes: 15 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Atypical regenerative hyperplasia esophageal

Elliot Weisenberg, M.D.
Page views in 2020: 1,336
Page views in 2021 to date: 1,152
Cite this page: Weisenberg E. Atypical regenerative hyperplasia. website. Accessed October 22nd, 2021.
Definition / general
  • Associated with chronic esophagitis, not neoplasia
  • Also called reactive hyperplasia, pseudoepitheliomatous hyperplasia
Microscopic (histologic) description
  • Architectural uniformity of immature and relatively monotonous sized small / medium keratinocytes mixed with inflammatory cells
  • Pleomorphism and atypia are common in keratinocytes and endothelial cells
  • Also mitotic figures
  • No cytoarchitectural pleomorphism, no desmoplasia
Differential diagnosis
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