Crohn's disease

Topic Completed: 1 October 2012

Minor changes: 15 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Crohn's disease esophagus[TI]

Elliot Weisenberg, M.D.
Page views in 2020: 636
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Cite this page: Weisenberg E. Crohn's disease. website. Accessed October 22nd, 2021.
Definition / general
  • Cannot definitely diagnose on biopsy, need resection specimen; however, can suggest diagnosis with appropriate findings
  • Associated with GI Crohn's disease; esophageal involvement in 0.2 - 13% with ileocolic Crohn's disease
  • Usually extraesophageal Crohn's disease at time of presentation in esophagus (Inflamm Bowel Dis 2001;7:113)
  • Isolated esophageal involvement is extremely rare; when first diagnosed in esophagus, intestinal involvement usually follows
  • Clinical and endoscopic appearances are highly variable and may not correlate (J Pediatr Gastroenterol Nutr 2003;36:454)
Case reports
Gross description
  • Early: mucosal hyperemia and aphthous ulcers
  • Late: discrete ulcers of lower 2/3, fibrosis, stenosis, fistulas
Microscopic (histologic) description
  • Deep and aphthoid ulcers, transmural inflammation, nonnecrotizing granulomas, epithelioid nonnecrotizing granulomas in 7 - 9% (Am J Gastroenterol 1997;92:1467)
Positive stains
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