Other nonneoplastic

Glycogenic acanthosis

Topic Completed: 1 November 2012

Minor changes: 21 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Glycogenic acanthosis esophagus

Elliot Weisenberg, M.D.
Page views in 2020: 4,564
Page views in 2021 to date: 4,985
Cite this page: Weisenberg E. Glycogenic acanthosis. website. Accessed October 22nd, 2021.
Definition / general
Gross description
  • Multiple white mucosal plaques < 1 cm; may resemble leukoplakia; polypoid lesions may occur in syndromic patients
Gross images

AFIP images

Numerous white islands

Slightly elevated longitudinal plaque

Images hosted on other servers:

White nodules

Microscopic (histologic) description
  • Epithelial thickening by large squamous cells of prickle cell layer packed with glycogen; no atypia, no inflammation
Microscopic (histologic) images

AFIP images

Thickened superficial squamous
epithelium with enlarged
squamous cells containing abundant
pale to clear cytoplasm

 Contributed by Dr. Mark R. Wick

Glycogen patch

Glycogen patch undigested PAS stain

Glycogen patch digested PAS stain

Images hosted on other servers:

Large squamous cells with abundant cytoplasm

Positive stains
  • PAS (glycogen), diastase sensitive
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