Indefinite for dysplasia

Topic Completed: 1 May 2013

Minor changes: 21 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Indefinite for dysplasia esophagus[TIAB]

Elliot Weisenberg, M.D.
Page views in 2020: 1,284
Page views in 2021 to date: 1,322
Cite this page: Weisenberg E. Indefinite for dysplasia. website. Accessed October 22nd, 2021.
Definition / general
  • These patients are at risk for adenocarcinoma - rebiopsy after antireflux treatment
  • Limit diagnosis to cases in which changes are too marked for negative but insufficient for dysplasia
  • Diagnosis may be due to suboptimal tissue processing, loss of surface epithelium, cautery artifact (Histopathology 2000;37:99)
Microscopic (histologic) description
  • Dysplastic-like epithelial atypia in background of active neutrophilic inflammation and mucosal erosion
  • Architecture may be moderately distorted; nuclear abnormalities less marked than dysplasia; may have more numerous dystrophic goblet cells, more extensive nuclear stratification, diminished or absent mucus production, increased cytoplasmic basophilia or increased mitoses
Microscopic (histologic) images

AFIP images

Crowding of lower portions of
glands with maturation towards
surface but some stratification
and nuclear enlargement


Enlarged, hyperchromatic, spindled and
stratified nuclei; also dystrophic
goblet cells with nuclei displaced
towards luminal surface of cell


Enlarged nuclei are pseudostratified
and crowded in lower crypt but
nuclear changes are less
pronounced towards surface

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Indefinite for dysplasia

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