Eye
Conjunctiva
Conjunctivitis
Cicatrizing conjunctivitis
Author: Deepali Jain, M.D.
Last author update: 1 September 2013
Last staff update: 22 December 2020
Copyright: 2004-2023, PathologyOutlines.com, Inc.
PubMed Search: Cicatrizing conjunctivitis
Table of Contents
Definition / general | Etiology | Clinical features | Diagnosis | Treatment | Microscopic (histologic) descriptionCite this page: Jain D. Cicatrizing conjunctivitis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyecicatrizingconj.html. Accessed September 28th, 2023.
Definition / general
- Cicatrizing: causing a scar and possibly affecting vision
- Conjunctival fibrosis due to chronic inflammation, leading to alterations of conjunctival architecture
Etiology
- Numerous causes (Curr Opin Ophthalmol 2001;12:250)
- Atopic keratoconjunctivitis
- Burns
- Discoid lupus erythematosus (Ocul Immunol Inflamm 2002;10:287)
- Epidermolysis bullosa acquisita (Arch Ophthalmol 2006;124:1615)
- Lichen planus (Am J Ophthalmol 2003;136:239)
- Ocular cicatricial pemphigoid
- Ocular rosacea (Cornea 2004;23:630)
- Paraneoplastic syndrome associated with lung tumors (Cornea 2006;25:611)
- Porphyria cutaneous tarda (Am J Ophthalmol 2002;134:619)
- Post-infectious
- Sarcoidosis (Ann Ophthalmol 1989;21:92)
- Sjögren syndrome
- Stevens-Johnson syndrome
- Systemic sclerosis
- Trachoma
- Granulomatosis with polyangiitis (Wegener's) (Nephrol Dial Transplant 2006;21:3342)
Clinical features
- Dry eyes
- Loss of transparency and vision
Diagnosis
- Positive direct immunofluorescence with IgA, IgM, IgG, complement C3, complement C4, and fibrinogen in autoimmune diseases
Treatment
- Medical management varies according to specific causes
Microscopic (histologic) description
- Fibrosis and inflammation consisting of neutrophils, lymphocytes, plasma cells
- Keratinization of superficial layer, hyperplasia of basal layers
