Mesenchymal tumors

Kaposi sarcoma-conjunctiva

Topic Completed: 1 September 2013

Minor changes: 24 December 2020

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PubMed Search: Kaposi sarcoma conjunctiva

Nat Pernick, M.D.
Page views in 2020: 259
Page views in 2021 to date: 254
Cite this page: Pernick N. Kaposi sarcoma-conjunctiva. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeconjkaposi.html. Accessed December 4th, 2021.
Definition / general
  • See also Soft Tissue chapter
  • Historically present in up to 20% of AIDS patients
  • First manifestation of disease in 4 - 14%
  • Dugel classification (Ophthalmology 1992;99:1127)
  • Type I: patchy, flat, < 3 mm thick, thin dilated vascular channels lined by endothelial cells, no spindle cells, no mitotic activity
  • Type II: flat tumors < 3 mm thick, empty vascular channels linked by plump, fusiform endothelial cells with hyperchromatic nuclei, few spindle cells, no mitotic figures
  • Type III: nodular, 3 mm or more, packed spindle cells with hyperchromatic nuclei and mitotic figures, slit-like spaces with RBCs
Case reports
  • Local excision with 1 - 2 mm margins plus cryotherapy
  • Type III tumors often recur
Clinical images

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Elevated nodule arising from fornix

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Multinodular conjunctival mass

Microscopic (histologic) description
  • Swollen endothelial type cells with slit-like vessels
  • Advanced lesions have spindle cells and mitotic figures
Microscopic (histologic) images

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Subepithelial proliferation of spindle cells and vessels

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Biphasic subepithelial tumor

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Swollen endothelial cells

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Enlarged endothelial cell contains a cluster of hyaline globules

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Spindle cells with extravasated RBCs

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Scattered endothelial lined spaces

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