Hematopoietic tumors


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Last staff update: 24 December 2020

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PubMed Search: Lymphoma conjunctiva [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Lymphoma-conjunctiva. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeconjlymphoma.html. Accessed November 29th, 2023.
Definition / general
  • Usually indolent MALT lymphomas - difficult to predict malignant potential
  • Often remains an isolated lesion
  • May be preceded by apparently reactive lymphoid hyperplasia
  • Mantle cell lymphomas have more aggressive behavior with median survival of 3 - 5 years
  • H&E for high grade lesions
  • For low grade lesions, need fresh tissue for flow cytometry or gene rearrangement studies
  • Immunohistochemistry (light chain restriction)
Case reports
Gross description
  • Salmon colored mass or masses
Microscopic (histologic) description
  • MALT: well differentiated, monoclonal small B lymphocytes, occasionally exhibits overt monocytoid cytology, prominent plasmacytic features or lymphoepithelial lesions (Am J Surg Pathol 2007;31:792)
Molecular / cytogenetics description
  • MALT may have t(14;18)(q32;q21) involving IgH and MALT1 genes
  • B cell clonality in 55% of MALT and 60% of diffuse large B cell lymphomas (Mod Pathol 2001;14:641)
Additional references
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