Other tumors

Squamous cell carcinoma-eyelid

Topic Completed: 1 February 2014

Minor changes: 29 December 2020

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PubMed Search: Squamous cell carcinoma [title] eyelid [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Squamous cell carcinoma-eyelid. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeeyelidscc.html. Accessed December 6th, 2021.
Definition / general
  • 10% of carcinomas in eyelid
  • Usually lower lid
  • Rarely are adenoid (pseudoglandular)
  • Rarely invade eye or orbit or metastasize
Gross description
  • Elevated and thickened areas of eyelid, may be ulcerated or friable
Microscopic (histologic) description
  • Invasion of malignant squamous cells into dermis
  • Cells are large and eosinophilic with marked atypia
  • Often abnormal deep keratinization, may have keratin pearls
Microscopic (histologic) images

AFIP images

Squamous cell carcinoma - spindle cell type
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Atrophic epidermis over a highly infiltrative tumor

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Spindled cells resemble sarcoma

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