Eye
Eyelid
Other tumors
Squamous cell carcinoma-eyelid
Author: Nat Pernick, M.D.
Last author update: 1 February 2014
Last staff update: 29 December 2020
Copyright: 2004-2023, PathologyOutlines.com, Inc.
PubMed Search: Squamous cell carcinoma [title] eyelid [title]
Table of Contents
Definition / general | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Pernick N. Squamous cell carcinoma-eyelid. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeeyelidscc.html. Accessed September 28th, 2023.
Definition / general
- 10% of carcinomas in eyelid
- Usually lower lid
- Rarely are adenoid (pseudoglandular)
- Rarely invade eye or orbit or metastasize
Gross description
- Elevated and thickened areas of eyelid, may be ulcerated or friable
Microscopic (histologic) description
- Invasion of malignant squamous cells into dermis
- Cells are large and eosinophilic with marked atypia
- Often abnormal deep keratinization, may have keratin pearls
Microscopic (histologic) images
AFIP images
Squamous cell carcinoma - spindle cell type
Atrophic epidermis over a highly infiltrative tumor
Spindled cells resemble sarcoma
Differential diagnosis
- Actinic keratosis
- Inverted follicular keratosis
- Keratoacanthoma
- Pseudoepitheliomatous hyperplasia
- Seborrheic keratosis
- Squamous papilloma
