Epithelial tumors


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Last staff update: 19 May 2022

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PubMed Search: Keratoacanthoma conjunctiva

Deepali Jain, M.D.
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Cite this page: Jain D. Keratoacanthoma-conjunctiva. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyekeratoacanthoma.html. Accessed December 10th, 2022.
Definition / general
  • Uncommon, rapidly growing, squamous cell proliferation of sun exposed bulbar conjunctiva
  • Grows for weeks, then regresses or stays unchanged
Case reports
  • Excision; may need cryotherapy of margins due to possibility of malignant diagnosis; only rarely recurs
Clinical images

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White, dome shaped mass

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Mobile conjunctival mass

Gross description
  • Crater like
Microscopic (histologic) description
  • Lobules of proliferating squamous epithelium, often mitotic figures
  • Deep edges are well circumscribed and regular appearing
  • Epithelial cells are glassy with vesicular nuclei and prominent eosinophilic nucleoli
  • No / rare parakeratosis
  • Often acute and chronic inflammatory cells which extend into adjacent epithelium
Microscopic (histologic) images

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Central crater containing keratotic plug

Differential diagnosis
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