Lens & vitreous humor

Persistent hyperplastic primary vitreous

Last author update: 1 February 2014
Last staff update: 27 May 2022

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PubMed Search: Persistent hyperplastic primary vitreous

Nat Pernick, M.D.
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Cite this page: Pernick N. Persistent hyperplastic primary vitreous. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyelenspersistenthyperplasticprimaryvitreous.html. Accessed October 4th, 2023.
Definition / general
  • Congenital, due to incomplete regression of fetal vasculature of vitreous humor, producing a retrolental mass
  • Usually unilateral
  • Associated with small eye, white reflex behind pupil (leukokoria), fibrous tissue behind lens, often cataract
  • Retina normal or with retinal dysplasia
Radiology images

AFIP images
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CT scan: microphthalmic eye

Gross images

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Mild microphthalmos

Clinical images

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Wrinkling and rupture of posterior lens capsule

Microscopic (histologic) description
  • Dense fibrovascular retrolental mass containing elongated ciliary processes and part of hyaloid vascular system
Whole mount images

AFIP images
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Falciform fold of detached dysplastic retina

Microscopic (histologic) images

AFIP images
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Retrolental mass

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Retrolental fibrovascular mass

Differential diagnosis
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