Lens & vitreous humor

Phacoanaphylactic endophthalmitis

Last author update: 1 February 2014
Last staff update: 28 December 2020

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PubMed Search: Phacoanaphylactic endophthalmitis [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Phacoanaphylactic endophthalmitis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyelensphacoanaphylaxis.html. Accessed September 21st, 2023.
Definition / general
  • Usually occurs after penetrating injuries to lens
  • Rarely due to spontaneous rupture of swollen lens with a cataract
  • Granulomatous reaction may be due to acquired hypersensitivity to lens proteins
  • May coexist with sympathetic uveitis
Microscopic (histologic) description
  • Granulomatous inflammation surrounding area of lens perforation, with zonal pattern of central neutrophils around disintegrating lens fibers and peripheral macrophages, epithelioid cells and giant cells
  • Posterior synechiae usually present
  • Usually perivasculitis of retinal vessels
  • Variable plasma cells in iris
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