Melanocytic tumors

Inflammatory juvenile conjunctival nevus

Last author update: 1 October 2014
Last staff update: 4 March 2021

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PubMed Search: Inflammatory juvenile conjunctival nevus

Related Topics: Nevi

Deepali Jain, M.D.
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Cite this page: Jain D. Inflammatory juvenile conjunctival nevus. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyenevijuvenile.html. Accessed September 28th, 2023.
Definition / general
  • Benign, inflammatory juxtalimbal lesion characterized by marked eosinophils
  • Children and teenagers
  • May grow rapidly and cause congestion, and clinically resemble melanoma
  • Associated with systemic allergies and bilateral papillary conjunctivitis (Br J Ophthalmol 2002;86:28)
  • Excision and close follow up
Microscopic (histologic) description
  • Confluent growth pattern and a lack of maturation
  • Epithelial cysts and solid islands composed of benign nevus cells
  • Also prominent eosinophils and mast cells (some degranulated)
  • Often lymphocytes (52%) and lymphoid follicles (Invest Ophthalmol Vis Sci 2002;43:1850) and plasma cells
  • MUC5AC in enlarging cysts (Jpn J Ophthalmol 2012;56:107)
Microscopic (histologic) images

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Various images

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Nerve growth factor and eosinophils

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IHC for NGF and eosinophils

Additional references
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