Other nonneoplastic

Ocular cicatricial pemphigoid

Last author update: 1 April 2013
Last staff update: 27 May 2021

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PubMed Search: Ocular cicatricial pemphigoid conjunctiva [title]

Deepali Jain, M.D.
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Cite this page: Jain D. Ocular cicatricial pemphigoid. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeocularcicatricialpemphigoid.html. Accessed September 21st, 2023.
Definition / general
  • Also called mucus membrane pemphigoid of conjunctiva
  • Mucocutaneous autoimmune disorder
  • Bilateral; only rarely unilateral (Cornea 2010;29:1462)
  • Usually age 50+ years, more common in women
  • 50% of cases involve conjunctiva, usually 10 years or more after onset of cutaneous or other mucosal disease; may occasionally demonstrate purely ocular disease (Ophthalmology 1999;106:355)
  • Uncontrolled cases are associated with infection (Cornea 2004;23:819)
  • Rarely presents with corneal ulceration (Eur J Ophthalmol 2007;17:121)
  • Impression cytology may be useful for diagnosis (Arch Soc Esp Oftalmol 2004;79:67)
  • Divide sample in two - one for formalin, one in transport media for immunofluorescent studies
Case reports
Clinical images

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Cicatrizing conjunctivitis

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Slit lamp photograph showing bullae

Microscopic (histologic) description
  • Early - epithelial erosions and bullae
  • Late - epithelial and stromal scarring, perivascular lymphocytes and plasma cells
Microscopic (histologic) images

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Inflamed conjunctiva

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Subepidermal bullous dermatosis

Positive stains
Electron microscopy description
Differential diagnosis
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