Orbit & optic nerve

Idiopathic sclerosing inflammation

Topic Completed: 1 February 2014

Minor changes: 24 December 2020

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PubMed Search: Idiopathic sclerosing inflammation [title] orbit

Nat Pernick, M.D.
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Cite this page: Pernick N. Idiopathic sclerosing inflammation. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeorbitidiopathicsclerosing.html. Accessed December 3rd, 2021.
Definition / general
  • Insidious, chronic and progressive fibrosing process
  • Damages orbital structures by entrapment and mass effect
  • May have cell mediated pathogenesis, similar to retroperitoneal fibrosis (Mod Pathol 1993;6:581)
Microscopic (histologic) description
  • Desmoplasia, sparse lymphocytes (usually T cells), histiocytes, plasma cells, neutrophils, eosinophils
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