Eye
Orbit & optic nerve
Lymphoma-orbit
Author: Nat Pernick, M.D.
Last author update: 1 February 2014
Last staff update: 20 May 2022
Copyright: 2004-2023, PathologyOutlines.com, Inc.
PubMed Search: Lymphoma orbit
Table of Contents
Definition / general | Radiology images | Case reports | Clinical images | Microscopic (histologic) images | Positive stains | Differential diagnosisCite this page: Pernick N. Lymphoma-orbit. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeorbitlymphoma.html. Accessed September 21st, 2023.
Definition / general
- Tumors composed of small lymphocytic proliferations confined to orbit are usually indolent and associated with long survival, even with minimal treatment
- MALT lymphoma:
- Uniform and monotonous proliferation of small lymphocytes infiltrating into orbital fat, blood vessels and nerves
- May have plasmacytoid features with Dutcher bodies (intranuclear inclusions) and serum paraproteinemia
- Light chain restriction
Radiology images
AFIP images
Homogeneous tumor
Case reports
- 5 year old girl with an angiocentric orbital lesion with an immature natural killer cell immunophenotype (Hum Pathol 2001;32:339)
- Nasal-type NK/T cell lymphoma of the orbit with distant metastases (Hum Pathol 2003;34:290)
Clinical images
AFIP images
Burkitt lymphoma: bilateral
Lymphoplasmacytic lymphoma: bilateral
Microscopic (histologic) images
AFIP images
Low grade tumor
Well differentiated lymphoma
Irregularly shaped mass
Uniform population of well differentiated lymphocytes
Small cleaved cells
Small population of T cells
Numerous CD20+ B cells
Burkitt lymphoma
Granulocytic leukemia - Leder stain positive
Lymphoplasmacytic lymphoma - lymphoid cells, some with plasmacytic differentiation
Positive stains
- Monotypic immunoglobulins
Differential diagnosis
- Lymphoid hyperplasia:
- Polymorphic lymphocytes, vascular proliferation, prominent follicles with germinal centers
