Other nonneoplastic

Pseudoepitheliomatous hyperplasia

Last author update: 1 October 2014
Last staff update: 28 December 2020

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PubMed Search: Pseudoepitheliomatous hyperplasia conjunctiva

Deepali Jain, M.D.
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Cite this page: Jain D. Pseudoepitheliomatous hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyepseudoepitheliomatoushyperplasiaconjun.html. Accessed December 10th, 2022.
Definition / general
  • Response to chronic conjunctival irritation or inflammation
  • Develops rapidly, may ulcerate
Case reports
  • Remove cause of inflammation
Gross description
  • Pink mass with leukoplakia
Microscopic (histologic) description
  • Reactive epithelial proliferation with irregular lobules containing variable acanthosis and keratinization, parakeratosis
  • Reactive epithelial changes, inflammation and mitotic activity
  • May have ill defined border with subepithelial connective tissue due to inflammation
  • No nuclear atypia
Microscopic (histologic) images

AFIP images
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Resembles squamous cell carcinoma

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Infiltrating squamous cells are benign

Differential diagnosis
  • Fungi: multinucleated giant cells
  • Pseudoadenomatous hyperplasia: reactive gland-like proliferation resembling mucoepidermoid carcinoma
  • Squamous cell carcinoma: atypical cells, individual cell keratinization
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