Conjunctiva: pseudoepitheliomatous hyperplasia

Eye
Conjunctiva
Pseudoepitheliomatous hyperplasia

Author: Deepali Jain, M.D.

Topic Completed: 1 October 2014

Revised: 26 March 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Pseudoepitheliomatous hyperplasia conjunctiva

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Table of Contents

Cite this page: Jain D. Conjunctiva: pseudoepitheliomatous hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyepseudoepitheliomatoushyperplasiaconjun.html. Accessed February 20th, 2020.

Definition / general

Response to chronic conjunctival irritation or inflammation
Develops rapidly, may ulcerate

Case reports

12 year old girl post-limbal epithelium transplant (Clin Experiment Ophthalmol 2006;34:889)
Associated with granular cell tumor (Am J Ophthalmol 1981;91:234)

Treatment

Remove cause of inflammation

Gross description

Pink mass with leukoplakia

Microscopic (histologic) description

Reactive epithelial proliferation with irregular lobules containing variable acanthosis and keratinization, parakeratosis
Reactive epithelial changes, inflammation and mitotic activity
May have ill defined border with subepithelial connective tissue due to inflammation
No nuclear atypia

Microscopic (histologic) images

AFIP images

Resembles squamous cell carcinoma

Infiltrating squamous cells are benign

Differential diagnosis

Fungi: multinucleated giant cells
Pseudoadenomatous hyperplasia: reactive gland-like proliferation resembling mucoepidermoid carcinoma
Squamous cell carcinoma: atypical cells, individual cell keratinization