Eye
Conjunctiva
Other nonneoplastic
Pseudoepitheliomatous hyperplasia
Author: Deepali Jain, M.D.
Topic Completed: 1 October 2014
Minor changes: 28 December 2020
Copyright: 2004-2021, PathologyOutlines.com, Inc.
PubMed Search: Pseudoepitheliomatous hyperplasia conjunctiva
Table of Contents
Definition / general | Case reports | Treatment | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Jain D. Pseudoepitheliomatous hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyepseudoepitheliomatoushyperplasiaconjun.html. Accessed January 22nd, 2021.
Definition / general
- Response to chronic conjunctival irritation or inflammation
- Develops rapidly, may ulcerate
Case reports
- 12 year old girl post-limbal epithelium transplant (Clin Experiment Ophthalmol 2006;34:889)
- Associated with granular cell tumor (Am J Ophthalmol 1981;91:234)
Treatment
- Remove cause of inflammation
Gross description
- Pink mass with leukoplakia
Microscopic (histologic) description
- Reactive epithelial proliferation with irregular lobules containing variable acanthosis and keratinization, parakeratosis
- Reactive epithelial changes, inflammation and mitotic activity
- May have ill defined border with subepithelial connective tissue due to inflammation
- No nuclear atypia
Microscopic (histologic) images
AFIP images
Resembles squamous cell carcinoma
Infiltrating squamous cells are benign
Differential diagnosis
- Fungi: multinucleated giant cells
- Pseudoadenomatous hyperplasia: reactive gland-like proliferation resembling mucoepidermoid carcinoma
- Squamous cell carcinoma: atypical cells, individual cell keratinization
