Visceral larva migrans

Topic Completed: 1 February 2014

Minor changes: 29 December 2020

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PubMed Search: Visceral larva migrans retina

Nat Pernick, M.D.
Page views in 2020: 125
Page views in 2021 to date: 204
Cite this page: Pernick N. Visceral larva migrans. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeretinaviscerallarvamigrans.html. Accessed December 3rd, 2021.
Definition / general
  • A type of nematodiasis (parasitic disease)
  • Somewhat common in US and Great Britain
  • Usually produced by Toxocara canis in children ages 3 - 14 years without systemic disease
  • Single migrating larva enters eye hematogenously and rests in vitreous or inner surface of retina with accompanying acute and chronic inflammatory cells and intense eosinophilia
  • Late changes are scarring, retinal detachment and leukokoria, simulating retinoblastoma
  • Dead larvae may cause minute granulomas, found with serial sectioning
Gross images

AFIP images
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White sclerotic vitreous
mass causing traction
related total retinal

Microscopic (histologic) images

AFIP images
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Vitreous mass contains
collagen (trichrome stain)
and causing total
retinal detachment

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Larva is surrounded by
acidophilic material (Splendore-
Hoeppli phenomenon) and
scattered eosinophils

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