Epithelial tumors

Steatocystoma simplex

Last author update: 1 July 2013
Last staff update: 10 June 2022

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PubMed Search: Steatocystoma simplex eye

Deepali Jain, M.D.
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Cite this page: Jain D. Steatocystoma simplex. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyesteatocytomasimplex.html. Accessed October 2nd, 2023.
Definition / general
  • Rare benign adnexal tumor, usually in caruncle
  • Steatocystoma simplex if solitary; steatocystoma multiplex if multiple cysts
  • Due to nevoid malformation of pilosebaceous duct junction
  • Autosomal dominant trait in multiplex
Clinical features
  • Typically affects individuals younger than 30 years; contains yellow sebum associated with hairs
Case reports
  • Simple excision with removal of cyst wall intact
Clinical images

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Pale yellow lesion

Gross description
  • Flesh colored or yellowish, well circumscribed, soft, mobile, and non-tender
  • On incision contains oily sebum
Microscopic (histologic) description
  • Cystic space lined by nonkeratinizing squamous epithelium with an eosinophilic cuticle and sebaceous lobules within the cyst wall, but no granular layer
Microscopic (histologic) images

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Cyst lined by
squamous epithelium
with sebaceous glands
in cyst wall

Differential diagnosis
  • Keratinous cyst:
    • Older adults, no sebaceous glands in or adjoining wall
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