Fallopian tubes & broad ligament
Fallopian tube tumors
Adenomatoid tumor
Authors: Nicole Riddle, M.D., Jamie Shutter, M.D.
Topic Completed: 1 September 2013
Minor changes: 30 December 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: Adenomatoid tumor fallopian tubes
Table of Contents
Definition / general | Sites | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosisCite this page: Riddle N, Shutter J. Adenomatoid tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/fallopiantubesadenomatoid.html. Accessed January 22nd, 2021.
Definition / general
- Most common benign fallopian tube tumor, usually asymptomatic
- Also called benign mesothelioma
- Often occurs in middle aged or older females
- May be due to invaginations of visceral mesothelium
Sites
- Uterus, ovary, para-ovarian
- Similar behavior as tumor in paratesticular region
Gross description
- Usually incidental, unilateral, microscopic finding within myosalpinx (muscle layer)
- May be circumscribed, gray white yellow, firm nodule up to 3 cm
Gross images
AFIP images
Well circumscribed mass
Microscopic (histologic) description
- Usually tubular spaces of varying size composed of flattened cells resembling endothelium
- Rarely large cells with eosinophilic cytoplasm
- Often with smooth muscle hyperplasia, lymphocytic follicles
- May have cytoplasmic vacuoles, infiltrative-like borders, clusters or small cords of cells
- Rare mitotic figures, minimal atypia
- May resemble vacuoles, fat cells, vessels, artifact
Microscopic (histologic) images
AFIP images
Tubal wall expanded
Slit-like, gland-like structures
Cysts are conspicuous
Vacuoles and gland-like spaces
Abundant eosinophilic cytoplasm with few vacuoles
Vacuoles and
gland-like
spaces separated
by scanty stroma
Images hosted on other servers:
Tubule-like spaces lined by flattened cells
Numerous tubular
structures
mimicking
vascular spaces
Flattened lining
Positive stains
- Calretinin, WT1, D2-40, thrombomodulin
- Cytokeratin AE1 / AE3, CAM 5.2, CK7, CK8, CK18, CK19 (Appl Immunohistochem Mol Morphol 2012;20:173)
- ER (80%), PR (80%) (same as mesothelial cells)
Negative stains
Differential diagnosis
- Adenomyoma: more prominent smooth muscle
- Invasive / metastatic well differentiated carcinoma: not circumscribed, more atypia and mitotic activity, different immunohistochemical profile
- Lymphangioma: cells very flattened, calretinin-
