Fallopian tubes & broad ligament

Fallopian tube nonneoplastic

Chronic salpingitis



Topic Completed: 1 March 2013

Minor changes: 13 July 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: Chronic salpingitis [title]

Nicole Riddle, M.D.
Jamie Shutter, M.D.
Page views in 2020: 10,267
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Cite this page: Riddle N, Shutter J. Chronic salpingitis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/fallopiantubeschronicsalpingitis. Accessed October 25th, 2021.
Clinical features
Pseudoxanthomatous salpingitis:
  • < 20 cases reported in English literature
  • Also known as pigmentosis tubae, xanthogranulomatous salpingingitis, xanthogranuloma, inflammatory pseudotumor, melanosis tubae (Int J Gynecol Pathol 2010;29:248)
  • Associated with chronic endometriosis (Mod Pathol 1993;6:53), often ovarian, also IUD and radiotherapy

Xanthogranulomatous salpingitis:
  • Rare, < 20 cases reported
  • Destructive inflammation of unknown cause characterized by accumulation of excessive foamy macrophages with accompanying lymphocytes, plasmocytes, few polymorphonuclear leukocytes (Clin Exp Obstet Gynecol 2008;35:291)
  • May represent hemorrhage in endometriotic foci (Ann Diagn Pathol 2007;11:117); may have infectious etiology
  • May simultaneously affect ovary
  • Symptoms: fever, lower abdominal or suprapubic pain, menorrhagia, vaginal bleeding, with adnexal tenderness and pelvic mass
Case reports
  • 48 year old with bilateral ovarian endometriosis and pseudogranulomatous salpinigits (Case #356)
Gross description
  • Enlarged distorted tube adherent to ovary
  • May be associated with hydrosalpinx or pyosalpinx that transforms to tubalovarian cyst
Gross images

AFIP images

Discolored mucosa


Microscopic (histologic) description
  • Blunted, shortened, fibrotic plica contain chronic inflammatory cells
  • Fused plica may produce a pseudoglandular pattern (chronic follicular salpingitis) that resembles malignancy
  • Pseudoxantomatous salpingitis: localized deposition of lipofuscin laden macrophages in lamina propria of fallopian tube with admixed chronic inflammatory cells
  • Xanthogranulomatous salpingitis: lipid containing macrophages, lymphocytes, plasma cells, neutrophils; variable multinucleated giant cells (Arch Pathol Lab Med 2001;125:260)
Microscopic (histologic) images

AFIP images

Various images

Cells with brown lipofuscin pigment expand tubal plicae



Case #356 - Pseudoxanthomatous salpingitis

Various images


Images hosted on other servers:

Fused and slightly thickened plicae

Differential diagnosis
  • Xanthogranulatous salpingitis may resemble malakoplakia, although it has Michaelis-Gutmann bodies
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