Fallopian tubes & broad ligament

Fallopian tube nonneoplastic

Salpingitis isthmica nodosa



Last author update: 1 August 2013
Last staff update: 14 June 2022

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PubMed Search: Salpingitis isthmica nodosa

Nicole D. Riddle, M.D.
Jamie Shutter, M.D.
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Cite this page: Riddle N, Shutter J. Salpingitis isthmica nodosa. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/fallopiantubessin.html. Accessed August 17th, 2022.
Definition / general
  • Fallopian tube epithelium outpouching into tubal wall
  • In severe cases, lumen may be completely obstructed
  • May also associated with endosalpingiosis
Terminology
  • Also called diverticulosis of fallopian tube
Epidemiology
  • Occurs in ~1% of Caucasians, 10% of African Americans
  • Young women, mean 26 years
  • 85% bilateral
Etiology
  • May be analogous to uterine adenomyosis
Clinical features
  • Associated with infertility in 50% but presence may not actually affect number of births (Hum Reprod 1991;6:828)
  • May lead to ectopic pregnancy
Case reports
Gross description
  • Usually well delineated, yellow white nodular swelling(s) up to 2 cm, usually isthmus, may be inconspicuous
Gross images

AFIP images
Salpingitis isthmica nodosa Salpingitis isthmica nodosa

Salpingitis isthmica nodosa



Images hosted on other servers:
Nodules at isthmus

Nodules at isthmus

Microscopic (histologic) description
  • Regularly spaced glands lined by normal appearing tubal epithelium within hypertrophied smooth muscle or surrounding fibrous tissue
  • Glands may be cystically dilated and are true diverticula that communicate with tubal lumen
  • Occasionally glands surrounded by endometrial type stroma
  • No significant atypia, stromal response minimal
Microscopic (histologic) images

AFIP images
Salpingitis isthmica nodosa Salpingitis isthmica nodosa

Salpingitis isthmica nodosa



Images hosted on other servers:
Lumen extension into hypertrophied muscular wall

Lumen extension into hypertrophied muscular wall

Cystically dilated glands within hypertrophied muscle wall

Cystically dilated
glands within
hypertrophied
muscle wall

Dilated glands trapped in muscle layer

Dilated glands trapped in muscle layer

Epithelial lining and subepithelial glands

Epithelial lining and subepithelial glands

Differential diagnosis
  • Carcinoma: both have irregular placement of glands but SIN has no atypia and minimal stromal response
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