Gallbladder & extrahepatic bile ducts
Gallbladder malignant
Carcinoma in situ
Author: Hanni Gulwani, M.B.B.S.
Topic Completed: 1 September 2012
Minor changes: 14 September 2021
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: Carcinoma in situ[TIAB] gallbladder
Cite this page: Gulwani H. Carcinoma in situ. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/gallbladderCIS.html. Accessed September 21st, 2021.
Definition / general
- Often an incidental finding after cholecystectomy for cholecystitis or cholelithiasis (Arch Pathol Lab Med 2010;134:1621)
- Not associated with tumor related death
Microscopic (histologic) description
- May extend into Rokitansky-Aschoff sinuses resembling invasive carcinoma but is connected to surface epithelium (Am J Surg Pathol 2004;28:621)
- Mixture of benign and neoplastic epithelium
- Has inspissated bile in long dilated spaces
- Desmoplasia but no invasion into smooth muscle bundles, no perineurial invasion
- May arise in adenomyomatous hyperplasia
