Gallbladder & extrahepatic bile ducts

Gallbladder malignant

Carcinoma in situ



Topic Completed: 1 September 2012

Minor changes: 14 September 2021

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PubMed Search: Carcinoma in situ[TIAB] gallbladder

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Carcinoma in situ. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/gallbladderCIS.html. Accessed September 21st, 2021.
Definition / general
Microscopic (histologic) description
  • May extend into Rokitansky-Aschoff sinuses resembling invasive carcinoma but is connected to surface epithelium (Am J Surg Pathol 2004;28:621)
  • Mixture of benign and neoplastic epithelium
  • Has inspissated bile in long dilated spaces
  • Desmoplasia but no invasion into smooth muscle bundles, no perineurial invasion
  • May arise in adenomyomatous hyperplasia
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