Gallbladder & extrahepatic bile ducts
Gallbladder nonneoplastic
Cholelithiasis
Author: Hanni Gulwani, M.B.B.S.
Topic Completed: 1 September 2012
Minor changes: 5 September 2019
Copyright: 2003-2019, PathologyOutlines.com, Inc.
PubMed Search: Cholelithiasis[TI] gallbladder[TI] full text[sb]
Table of Contents
Definition / general | Diagnosis | Treatment | Gross description | Microscopic (histologic) descriptionCite this page: Gulwani H. Cholelithiasis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/gallbladdercholelithiasis.html. Accessed August 6th, 2020.
Definition / general
- Also called gallstones
- Accounts for 1% of national heath care budget
- Affects 10% of adults in developed countries (80% are silent) vs. < 1% of children
- 80% of gallstones in West are cholesterol stones with 50% or more crystalline cholesterol monohydrate
- 20% of gallstones in West are pigment stones composed of bilirubin calcium salts
- Gallstones impact at neck just proximal to cystic duct
- Typically within lumen but may be intramural
Risk factors:
- Pima, Hopi or Navajo (75% of stones are pure cholesterol vs. 25% in industrialized vs. minimal in developing countries), also Scandinavians, Chileans, Mexican Americans, increasing age (> 50% risk by age 80)
- Fat, fertile [multiple pregnancies], forty, female, obesity (Korean J Gastroenterol 2012;59:27), rapid weight loss, gallbladder stasis, genetic disorders that impair bile salt synthesis / secretion or increase cholesterol levels (serum or biliary), low HDL levels
- May be influenced by Apolipoprotein E genotype (Ann Epidemiol 2006;16:763)
- Biliary sludge typically occurs before gallstones
- Estrogens from birth control pills or pregnancy increase expression of hepatic LDL receptors, which increase cholesterol uptake, which stimulate HMG CoA reductase, which synthesizes cholesterol
- Pigment stone risk factors are increased unconjugated bilirubin (from hemolytic syndromes, ileal dysfunction / bypass, bacterial contamination of biliary tree)
Clofibrate:
- Anticholesterol drug that increases HMG CoA reductase activity and decreases conversion of cholesterol to bile acids by reducing cholesterol 7 alpha hydroxylase activity, causes excess biliary secretion of cholesterol
Symptoms:
- Usually none but may have biliary colic (severe, right upper quadrant pain)
Complications:
- 1 - 2% have acute or chronic cholecystitis, choledocholithiasis, cholangitis, empyema, gallstone ileus, acute pancreatitis
Mirizzi syndrome:
- Rare
- Stone impacting in cystic duct or gallbladder neck causes extrinsic compression or obstruction of common bile duct, causing jaundice
Report:
- Presence of biliary sludge, number, size and type of gallstones
Diagnosis
- Ultrasound (95% sensitive and specific for gallstones 2 mm or larger or gallbladder sludge), Xrays detect 10 - 25% of gallstones that are radiopaque due to calcium
Treatment
- Laparoscopic cholecystectomy if symptomatic or in children, Native Americans, patients with sickle cell disease or porcelain gallbladder, stones 3 cm or larger
Gross description
- 85% are 2 cm or less
Microscopic (histologic) description
- Minimal / mild lymphocytic mucosal inflammation, Rokitansky-Aschoff sinuses, fibrosis, thickening of muscularis propria (Am J Surg Pathol 2003;27:1313), cholesterolosis, focal epithelial metaplasia (pyloric / gastric mucin cell metaplasia or intestinal metaplasia)
