Table of ContentsDefinition / general
Cite this page: Gulwani H. Dysplasia-carcinoma sequence. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/gallbladderdyplasiacarcinoma.html. Accessed July 5th, 2022.
Definition / general
- Suggested route for development of invasive carcinoma of gallbladder (Arch Pathol Lab Med 2005;129:386)
Gallstones → chronic inflammation → antral type metaplasia → intestinal metaplasia → dysplasia → carcinoma
- Major pathway to invasive gallbladder carcinoma is via dysplasia; adenomas do not appear to be important precursors
- Hyperplasia may not be part of this sequence