Gallbladder & extrahepatic bile ducts

Gallbladder dysplasia

Dysplasia-carcinoma sequence

Topic Completed: 1 September 2012

Minor changes: 30 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Dysplasia carcinoma sequence gallbladder

Hanni Gulwani, M.B.B.S.
Page views in 2020: 1,281
Page views in 2021 to date: 1,066
Table of Contents
Definition / general
Cite this page: Gulwani H. Dysplasia-carcinoma sequence. website. Accessed September 21st, 2021.
Definition / general
  • Suggested route for development of invasive carcinoma of gallbladder (Arch Pathol Lab Med 2005;129:386)

    Gallstones → chronic inflammation → antral type metaplasia → intestinal metaplasia → dysplasia → carcinoma

  • Major pathway to invasive gallbladder carcinoma is via dysplasia; adenomas do not appear to be important precursors
  • Hyperplasia may not be part of this sequence
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