Gallbladder & extrahepatic bile ducts
Cholecystitis
Eosinophilic cholecystitis
Author: Hanni Gulwani, M.B.B.S.
Topic Completed: 1 September 2012
Minor changes: 18 January 2021
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: Eosinophilic cholecystitis gallbladder
Table of Contents
Definition / general | Etiology | Case reports | Clinical images | Gross images | Microscopic (histologic) imagesCite this page: Gulwani H. Eosinophilic cholecystitis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/gallbladdereosinophilic.html. Accessed September 21st, 2021.
Definition / general
- Restrict usage to inflammatory infiltrates composed almost entirely of eosinophils, since eosinophils are common in subacute cholecystitis
- 1 - 5% of resected gallbladders
- Often involves muscular layer but may be transmural or mucosal
- Associated with gallstones, fibroblasts
- Churg-Strauss syndrome: granulomatous angiitis with eosinophilia
Etiology
- Idiosyncratic reaction to biliary contents
- Less commonly due to ampicillin, atopy, cephalosporin, eosinophilic cholangitis, eosinophilic enterocolitis or appendicitis, erythromycin, hypereosinophilic syndrome, interleukin 2 and lymphokine activated killer cells, lymphoplasmacytic sclerosing pancreatitis, parasitic infection, peripheral eosinophilia (Am J Surg Pathol 2003;27:334)
Case reports
- 29 year old obese man (Ann Clin Lab Sci 2007;37:182)
- 40 year old woman with ascariasis induced eosinophilic cholecystitis (HPB (Oxford) 2006;8:72)
- 40 year old woman (Cir Esp 2013;91:460)
Clinical images
Images hosted on other servers:
Thick gallbladder
with no evidence
of cyst or
lymph node
Gross images
Images hosted on other servers:
Very thick gallbladder wall
Microscopic (histologic) images
Images hosted on other servers:
Eosinophils infiltrating all layers of gallbladder wall
Eosinophils form
predominant
component of
inflammatory infiltrate
