Malignant tumors
Large cell neuroendocrine carcinoma

Topic Completed: 1 September 2012

Minor changes: 13 November 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Large cell neuroendocrine carcinoma gallbladder

Hanni Gulwani, M.B.B.S.
Page views in 2019: 463
Page views in 2020 to date: 184
Cite this page: Gulwani H. Large cell neuroendocrine carcinoma. website. Accessed May 29th, 2020.
Definition / general
  • Very rare (< 10 cases reported)
  • Similar to pulmonary counterpart
Case reports
Microscopic (histologic) description
  • Organoid growth pattern with rosettes and necrosis
  • Large cells, prominent nucleoli, coarse chromatin, high mitotic rate
  • May have intestinal metaplasia of tumor cells or adjacent mucosa
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
  • Endocrine markers
Back to top