Gallbladder & extrahepatic bile ducts
Gallbladder nonneoplastic
Metaplasia-gallbladder


Topic Completed: 1 September 2012

Minor changes: 30 December 2020

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PubMed Search: Metaplasia[TI] gallbladder

Hanni Gulwani, M.B.B.S.
Page views in 2020: 6,218
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Cite this page: Gulwani H. Metaplasia-gallbladder. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/gallbladdermetaplasia.html. Accessed January 17th, 2021.
Definition / general
  • Usually gastric or intestinal, rarely squamous
  • Associated with older age, gallstones
Bone metaplasia
Case reports
Cartilaginous metaplasia
Case reports
Gastric gland metaplasia
Definition / general
  • 66 - 84% of cholecystectomy specimens
  • Pyloric, antral or mucous glands
  • Glands usually scattered in lamina propria but may extend into muscular layer
  • May form polyps
  • Don't call adenoma unless dysplasia present


Microscopic (histologic) images

Images hosted on other servers:

Various images



Positive stains
Intestinal metaplasia
Definition / general
  • Very common finding in cholecystectomy specimens (up to 86%, Sao Paulo Med J 2008;126:220)
  • Goblet cells, endocrine cells, Paneth cells, absorptive cells
  • Also pyloric gland metaplasia
  • Rarely forms polyps


Case reports

Microscopic (histologic) images

Images hosted on other servers:

Various images



Additional references
Squamous metaplasia
Case reports
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