Malignant tumors
Sarcomatoid carcinoma

Topic Completed: 1 September 2012

Minor changes: 13 November 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Sarcomatoid carcinoma[TIAB] gallbladder

Hanni Gulwani, M.B.B.S.
Page views in 2019: 536
Page views in 2020 to date: 232
Cite this page: Gulwani H. Sarcomatoid carcinoma. website. Accessed May 29th, 2020.
Definition / general
  • Also called spindle cell carcinoma, carcinosarcoma
  • < 50 cases reported in gallbladder
  • Usually elderly women
  • Both components (spindled and epithelial) appear to be derived from single clone (Hum Pathol 2004;35:418)
  • Usually death within 6 months of diagnosis
Case reports
Gross description
  • Polypoid, firm, solid, yellowish gray, granular with necrosis
Gross images

Contributed by Dr. Semir Vranić

Microscopic (histologic) description
  • Malignant epithelial and sarcomatous components
  • Neoplastic glands contain mucin or rarely include squamous cell carcinoma
  • Sarcomatous component consists of pleomorphic or spindle cells, sometimes with heterologous osteosarcoma, chondrosarcoma or rhabdomyosarcoma
Microscopic (histologic) images

Contributed by Dr. Semir Vranić

Images hosted on other servers:

Tumor with rhabdoid component, CK+, vimentin+

Positive stains
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