Informatics, digital & computational pathology

Digital and whole slide imaging

WSI commercial platforms


Editorial Board Member: Jerome Cheng, M.D.
Deputy Editor-in-Chief: Patricia Tsang, M.D., M.B.A.
Nat Pernick, M.D.

Last author update: 28 July 2023
Last staff update: 8 September 2023

Copyright: 2023, PathologyOutlines.com, Inc.

PubMed Search: Whole slide imaging commercial platforms

Disclaimer: Information is accurate to the best of our knowledge and was gathered from public online sources

Nat Pernick, M.D.
Page views in 2023 to date: 636
Cite this page: Pernick N. WSI commercial platforms. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/informaticswsicommercialplatforms.html. Accessed September 21st, 2023.
Essential features
  • Whole slide imaging has become increasingly adopted by pathologists as a tool to digitalize pathology
  • Major manufacturers of whole slide scanners and 2 of each of their representative products are listed as a resource for the pathology community
  • Manufacturers appear in alphabetical order (see Table of Contents above)
  • Reference: J Pathol Inform 2021;12:50
3DHISTECH
  • 3DHISTECH is dedicated to providing clinical pathologists, researchers and universities with digital pathology solutions to facilitate quick and accurate diagnostics, support medical discoveries and foster education


PANNORAMIC® 1000 DX
  • High capacity and fast scanning (100 slides per hour)
  • Fully automated scanning operation
  • Image quality up to 41x / 82x optical magnification and 0.242 / 0.121 μm/pixel resolution
  • Slide logistics (supports Sakura slide cassettes and has a robotized loader)
  • Supports large format slides and multiple image formats (DICOM and MRXS)


PANNORAMIC 1000 demo




PANNORAMIC Flash DESK DX
  • High quality objectives, adapters and 12 MP camera with xenon flash illumination (up to 41x or 82x optical magnification and 0.242 or 0.121 μm/pixel resolution)
  • Double width slide compatibility with built in sensor to automatically detect slide type
  • AI based automated tissue detection for faster scanning
  • Compact design: small footprint (12 kg weight and 38 cm width)
  • Supports DICOM and MRXS image formats


PANNORAMIC DESK II DW demo




Akoya Biosciences
  • Akoya Biosciences is a spatial biology company that offers the most comprehensive end to end solutions for high parameter tissue analysis from discovery through clinical and translational research, enabling the development of more precise therapies for immuno-oncology and other drug development applications


PhenoImager HT
  • Multispectral imaging enables the identification and downstream quantification of multiple overlapping biomarkers (up to 8) without the interference of autofluorescence as the signals are unmixed from one another
  • Liquid crystal tunable filter (LCTF) technology generates unmixed, annotated regions of interest of up to 9 colors for deeper interrogation of biology
  • Generate unmixed whole slide scans at 40x magnification of up to 7 colors in about 20 minutes (15 x 15 mm region) for analysis of biology across the entire slide in a streamlined workflow and without selection bias
  • Digital whole slide scanning at 10 - 40x in brightfield or fluorescence
  • Enclosed system with built in touchless automation allows user to visualize, analyze, quantify and phenotype immune cells in situ with enhanced security and reliability
  • Integrated inForm and phenoptr tissue analysis software packages support configurable projects for biomarker quantification and spatial analysis


PhenoImager Fusion
  • Image multiple markers (up to 6) with sample to data in 24 hours
  • Accurate and quantitative data removal of autofluorescence interference and reduced fluorescence crosstalk
  • High speed automated digital whole slide scanning from 10x to 40x in brightfield or fluorescence
  • Scalable solution - easily integrate with PhenoCycler (formerly CODEX) to access high plex solutions
  • Integrated inForm® and phenoptrReports tissue analysis software packages support configurable projects for biomarker quantification and spatial analysis


PhenoImager - Akoya's patented multispectral imaging technology




Bionovation Biotech
  • Bionovation Biotech Inc. is aimed at using a signi´Čücant technological innovation to improve digital imaging in pathology with high speed, high magnification microscope scanners for hematology, microbiology and cytology and complete AI tools that enable the user to annotate and train AI apps by themselves and copyright them


CSFA800
  • Scan with 100x oil immersion objective for hematology, cytology and microbiology
  • Entire slide (20 x 40 mm) digitized in 3 minutes (100x oil objective)
  • AI algorithm detects and automatically sorts cells or other targets
  • Complete AI tools enable user to annotate and train AI apps themselves and copyright it


CSFA800-30




CSFA2000
  • Scan with 100x oil immersion objective for hematology, cytology and microbiology
  • Entire slide (20 x 40 mm) digitized in 1 minute (100x oil objective)
  • Fluorescence scanning available with TDI camera (60x oil APO NA1.4 objective, 2 minutes for entire slide, 1 color)
  • AI algorithm detects and automatically sorts cells or other targets
  • Complete AI tools enable user to annotate and train AI apps themselves and copyright it


Grundium
  • Grundium enables easy remote imaging for customers, ranging from individual clinics and hospitals to health systems all the way to enterprises providing laboratory services
  • Small footprint, high precision and affordable Ocus® microscope scanners are equally practical in various fields of microscopy, such as pathology, AI diagnosis, marine sciences, environmental research, geology and material sciences


Ocus®40
  • Image resolution: comparable magnification of 40x
  • Small footprint (18 x 18 x 19 cm)
  • Scan time of a 15 x 15 mm sample is ~180 seconds
  • Easy to use with only 15 minutes of training
  • Can be operated locally and remotely and pairs with any device with internet connection (computer, laptop, tablet)
  • Fits any workflow, supports all key file formats


Ocus®40 microscope scanner overview




Ocus®20
  • Comparable magnification of 20x; long 5 μm depth of field, continuous autofocus and Z stacking of up to 5 layers reveal sharp details even in less than perfect samples
  • Small footprint (18 x 18 x 19 cm); lightweight (3.5 kg)
  • Scan time of a 15 x 15 mm sample is ~60 seconds
  • Easy to use, with 15 minutes of training
  • Fits a variety of workflow, supports all key file formats
  • Pairs with any device with internet connection (computer, laptop, tablet)


Ocus®20 main features and key applications

Ocus®20 versus Ocus®40 microscope scanners comparison




Hamamatsu Photonics
  • Hamamatsu Photonics manufactures devices for the generation and measurement of visible, infrared and ultraviolet light
  • Hamamatsu is dedicated to the betterment of life through light based technologies


NanoZoomer S360 C13220-01
  • Scanning speed 20x or 40x mode (15 mm x 15 mm) is ~30s
  • Scans up to 360 standard slides automatically in one batch
  • Z stack feature included
  • Scans more than 82 slides/hour [40x mode]
  • Automated focus and image quality evaluation
  • Slide format: JPEG compressed image + slide information


NanoZoomer product range and its possibility




NanoZoomer S20 C16300-01
  • Scanning speed 20x or 40x mode (15 mm x 15 mm) is ~30s
  • Rapid throughput (20 slides in 15 minutes) (15 mm x 15 mm square with 5 focus points)
  • Flexible slide rack: load directly from Sakura 4768 20 slide basket and coverslipper for efficient scanner workflow
  • Z stack feature included
  • Scalable and compact: fits on a lab bench and is a scalable solution, as more scanners can be added as digitization needs increase
  • Slide format: JPEG compressed image


Introducing NanoZoomer S20MD slide scanner system




Huron Digital Pathology
  • Huron's solutions leverage 10+ years of experience in providing whole slide scanners to leading clinical and research institutions
  • Huron is on a mission to connect pathologists to the vast knowledge contained in the world's pathology reports


TissueScope™ iQ
  • Scanning capacity: up to 400 standard or 200 double wide slides and can mix standard and double wide cartridge slides
  • Scanning speed: < 1 minute per slide
  • Sharp, clear image quality up to 40x magnification
  • Z stack scanning
  • Nonproprietary file format, DICOM compatible


TissueScope™ LE
  • Scanning speed: < 1 minute per slide (15 mm x 15 mm @ 20x)
  • Sharp, clear image quality up to 40x magnification
  • Scan up to 12 standard 1" x 3" slides or any size up to 6" x 8" for unmatched versatility
  • Z stack scanning
  • Multiple file formats: nonproprietary 24 bit RGB pyramidal BigTIFF; uncompressed or JPEG 2000 compression; export to JPEG, flat TIFF and LZW compressed TIFF


TissueScope LE120 demonstration




KFBIO Digital Pathology
  • KFBIO is devoted to providing the most complete and suitable end to end digital pathology solutions for different customers, including digital pathology equipment, software and AI products
  • The company's vision is to promote the development of digital pathology and make digital pathology benefit human beings


KF-PRO-400
  • Scanning speed and capacity: 15 mm * 15 mm, 20x, 25s; supports 400 slides scanning at a time
  • Magnetic suspension motor drive; 99.85% slides scanned successfully
  • Resolution: 0.5 μm/pixel (20x), 0.25 μm/pixel (40x) WSI scanning; 20 nm positioning accuracy and supports 80x magnification
  • Compatibility: supports brightfield and fluorescence
  • Supports different image formats: KFB / TIFF / SVS


KFBIO 400 slides digital pathology scanner




KF-PRO-002
  • Slide capacity: 2 slides at a time (supports single slide fast manual loading)
  • Magnification and resolution: 20x, 0.5 μm/pixel ; 40x, 0.25 μm/pixel
  • Professional 3CCD linear camera, with 3 primary colors with independent color processing channel
  • 1 button operation
  • Z stack supported


KFBIO 2 slides scanner




Leica Biosystems
  • Leica Biosystems is a cancer diagnostics company that focuses on providing workflow solutions
  • Dedicated to driving innovations that connect people across radiology, pathology, surgery and oncology


Aperio GT 450
  • Scanning speed and capacity: 32 second scan speed (15 mm x 15 mm area at 40x); output 81 slides/hour at 40x; 450 slide capacity
  • No touch during scanning and continuous loading of the racks directly from the HistoCore Workstation (Stainer & Coverslipper)
  • Dedicated SAM (Scanner Administration Manager) server and software that allows the user to set up and monitor multiple Aperio GT 450s at a time; no more single workstations for each scanner
  • Automated IQ checks during each scan to ensure quality
  • 99.5% accurate tissue finder that allows the user to adjust if needed
  • Supports multiple image formats: DICOM compatible images, SVS, TIFF

Introducing Aperio GT 450




Aperio CS2
  • Easily load and scan up to five 1 x 3 slides
  • Slides are on the Aperio digital slide tray in 90 seconds (15 x 15 mm area at 20x)
  • External sharing and collaboration (institution to institution)
  • Internal sharing (Hub & Spoke Network) and collaboration
  • Scan success rate: > 98% first time
  • Adjustable tissue finder, if needed


Mikroscan
  • Mikroscan provides whole slide scanning systems for digital pathology and robotic microscopes for live, remote telemicroscopy
  • Mikroscan's vision is that every patient will receive the right diagnosis from the right expert at the right time, regardless of where they live in the world
  • Mikroscan is committed to partnering with the pathology community by providing technology enabled products and services that increase a pathologist's reach, remove barriers to workload efficiency and enable new discoveries


SL5-20
  • Capacity: 420 slides per day (15 x 15 mm specimen); load an entire case at once and view all slides live; scan or view 20 1 x 3" slides or 10 2 x 3" slides
  • Complete set of objectives - 2x, 4x, 10x, 20x and 40x - for true magnification (manual and automated focusing)
  • Capture and store individual and through focus regions of interest with Snapshots and Z Snaps
  • Time to view of 9 seconds per slide
  • Compact, portable unit fits on a desktop or cart
  • Little training required on the intuitive systems


Mikroscan SL5 live telemicroscopy mode




Motic Digital Pathology
  • Motic Digital Pathology addresses the growing global pathology care gap by making digital medicine approachable for hospitals, labs and doctors everywhere
  • Motic promotes adoption of telepathology through innovative, cost effective solutions developed directly in conjunction with partner pathologists
  • With direct manufacturing and 24/7 service and support, Motic's scanners and software drive faster, more reliable and more efficient work in healthcare, research and education


MoticEasyScan NEW Infinity
  • Scan 1,000+ slides per work week
  • No prescan preparation necessary
  • Apochromatic objective (40x, 0.13 μm/px) delivers color fidelity and high resolution whole slide imagery
  • True continuous loading
  • Z stack and EDF (with flexible scan modes for whole slide Z stack to accommodate thick samples)
  • Features allow for tissue detection without image premapping


MoticEasyScan NEW Infinity overview




MoticEasyScan One
  • Scan slides in as quick as 60 seconds
  • Tissue detection without premapping through a dedicated focus camera
  • Apochromatic objective (20x / 0.75) delivers color fidelity and high resolution 20x and 40x views
  • Multiple scan modes from Z stack for thick samples to high precision mode for wavy samples
  • Live remote microscopy: operate the scanner remotely to review slides for intraoperative consultations
  • Cloud or local storage: safe and secure options for storing, organizing and accessing slide images


How to get started with MoticEasyScan One




Nikon
  • Nikon Microscope Solutions unit is a part of the Nikon Healthcare Business Division of the Nikon Group of companies
  • The Microscope Solutions unit is focused on serving customers in research, biotech / pharma, the clinical laboratory and education with industry leading microscope based imaging solutions


BioPipeline Slide
  • Automated runs of up to 120 slides
  • Seamless tiled images in brightfield or fluorescence
  • Analysis toolbox: several analysis workflows and capabilities for user defined custom assays that can be applied to images
  • Storage: over 30x the storage capacity of a typical high end imaging workstation with expandability for more
  • Data transfer rates: exceed most traditional networks by 10 - 100x by using dedicated 10 GbE connections


OS-15-N
  • Slide capacity: 15 slides
  • Features Nikon's research grade Plan Apo Lambda objectives
  • Integrated AI & ML based image analysis tools for accurate, rapid and reproducible assessment
  • Computer assisted whole slide & ROI assessment with machine learning technology for accurate quantification of nuclear biomarker expression
  • Cloud enabled solutions IMAGEPath™ Image Management and TELEPath™ Telepathology


Objective Imaging
  • Objective Imaging is the market leading provider of automated digital microscopes for use in digital pathology and remote diagnostic applications
  • Objective Imaging specializes in whole slide scanning with its TurboScan™ scanning engine to provide an effective, reliable and affordable tool for the rapid acquisition of whole slide images from standard glass microscope slides


Glissando 20SL
  • Capacity: 20 standard or 10 mega slides
  • Compact system with integrated control computer
  • Flexible scan output formats for maximum compatibility
  • Available in 40x or 20x scanning objective configurations
  • Z stack acquisition included as standard


Glissando Desktop Scanner
  • Capacity for 2 standard slides or 1 mega slides
  • Compact system with integrated control computer
  • Flexible scan output formats for maximum compatibility
  • Available in 40x or 20x scanning objective configurations
  • Z stack acquisition included as standard


Glissando slide scanner live demo




OptraSCAN
  • Focused on delivering fully integrated digital pathology solutions that maximize quality, efficiency, affordability and throughput of customers' pathology labs, OptraSCAN provides a complete whole slide image solution system via an on demand, pay per use program to make digital pathology accessible to all


OS-Ultra
  • Slide capacity: 80, 160, 320 and 480 slides with continual slide loading capacity
  • Slides scanned at 0.25 microns per pixel (equivalent of 40x)
  • Scanning time is less than a minute for 15 x 15 mm region
  • Patented composite imaging for cytology samples
  • Images generated up to 0.1 microns per pixel (equivalent of 80x)
  • Cloud enabled storage for autostreaming data into cloud


OptraSCAN-OS-Ultra 320 digital pathology scanner launch




OS-Lite Brightfield Scanner
  • Slide capacity: 15 slides
  • Scanning speed (15 x 15 mm tissue area): 1 - 3 minutes for histology and cytology samples
  • Magnification: 20 or 40x
  • IMAGEPath Image Management system included for viewing, storing and archiving
  • TELEPath Telepathology included for real time remote consultations
  • Patented composite imaging ensuring 99% in focus slide images
  • Automated tissue detection


Digital pathology slide scanners - OptraSCAN




Philips Healthcare
  • Philips offers tools and resources for every stage of the pathology process, for a comprehensive, end to end experience that allows the user to digitize workflow, unify patient data, connect the teams with a scalable solution and gain new insights through real time collaboration


Pathology Scanner Second Generation SG300
  • Slides scanned at the equivalence of 40 times magnification (0.25 μm/pixel)
  • Scanner capacity: up to 60 slides per hour for a slide with 15 x 15 mm tissue size; slide capacity of 300 slides that can be continuously loaded
  • Automated operation supported by numerous algorithms for detection of tissue, barcode and coverslip as well as continuous autofocusing algorithms used during scanning
  • Multisite harmonization and security: a virtual network made up of multiple laboratories, allowing the user to connect the team with a scalable solution and sharing histology data across an organization
  • Real time collaboration: slide viewing with colleagues simultaneously in a manner that mimics a multiheaded microscope and with shared control of the screen


Pathology Second Generation Scanner SG20
  • Slides scanned at the equivalence of 40 times magnification (0.25 μm/pixel)
  • Scanner capacity: 20 slides that can be continuously loaded
  • Automated operation supported by numerous algorithms for detection of tissue, barcode and coverslip as well as continuous autofocusing algorithms used during scanning
  • Multisite harmonization and security: a virtual network made up of multiple laboratories, allowing the user to connect the team with a scalable solution and sharing histology data across an organization
  • Real time collaboration: slide viewing with colleagues simultaneously in a manner that mimics a multiheaded microscope and with shared control of the screen


Pramana
  • Pramana, Inc is a new health technology company from nference that enables digital transformation for next generation pathology at medical centers and pathology labs
  • Pramana offers a first in class digital pathology as a service (DPaaS) solution by providing a turnkey service offering with cutting edge whole slide imaging systems and a scalable software platform for clinical workflows
  • Pramana is a gateway for pathologists to utilize AI enabled decision support leveraging applications developed by nference and other healthcare technology companies


SpectralHT
  • Autonomous inline quality control
  • Scalable solution designed for high volume projects
  • Detects a variety of artifacts like annotations, debris, broken coverslip, stain deposits, bubbles, folds, uneven staining, very faint tissue, scratched glass
  • Up to 5 scanning clusters can be managed by a single operator for loading, unloading, operation and sign off for viewing by pathologists
  • Automated quality checks assess the quality of WSIs in a quantitative manner and with inline rescans to produce high quality images
  • Produces WSIs with < 0.5% imaging errors, 99% of the time


Digital pathology 2.0, Pramana robots in action




  • Contact Pramana for more information
PreciPoint
  • PreciPoint's mission is to digitize microscopy workflows by providing digital microscopes, scanners, software and consulting for laboratories


M8
  • Live, Instant Scan and Slide Scan modes allow the user to directly work on the sample, perform various analyses and scan the slides for documentation and future viewing
  • 10 second dual sample image overview picture
  • 1x - 850x zoom and live stitching with interchangeable objectives
  • Handles oversized glass slides
  • Automated Z axis and Z stacking
  • Portable size: 45 cm x 40 cm x 30 cm; 25 kg


Digital microscope & scanner - PreciPoint M8




O8
  • Unique solution for oil immersion, whole slide scanning and complete solution for digital microscopy
  • Scan entire slides and selected regions of interest with air and oil lenses up to 100x
  • View specimen on glass slides in high magnification in 3 different modes (Live, InstantScan, Scan and digitize specimen [whole slide image] on glass slides for documentation and further examinations)
  • Cloud storage and image analysis: cloud solutions, virtual classrooms and powerful image analysis tools
  • For various applications as in hematology or oncology research
  • Live remote control from anywhere while collaborating with colleagues


Roche Diagnostics
  • Roche Diagnostics develops innovative products and services that address the prevention, diagnosis, monitoring, screening and treatment of diseases


VENTANA DP 600
  • Scanning speed: scans at 20x magnification in ~36 seconds and at 40x magnification in ~73 seconds (15 mm x 15 mm areas of interest [AOIs])
  • Scanner capacity: 240 slide capacity, 40 trays of 6 single slides; continuous tray loading
  • No slide handling: tray based system eliminates slide handling errors, such as breakage and loss of slides, for improved reliability
  • Dynamic focus technology tracks tissue depth in real time and utilizes the data for high resolution images
  • Supports multiple file formats: BIF, TIF and DICOM


VENTANA DP 200
  • High speed scanning: scans at 20x magnification in ~36 seconds and at 40x magnification in ~73 seconds (15 mm x 15 mm AOIs)
  • No slide handling: slides are loaded and scanned using a tray based system, which eliminates slide handling errors and improves reliability
  • Dynamic focus: tracks tissue depth in real time and uses the data for high resolution slide scanning
  • Calibration: automatic white balance calibration to ensure consistent image quality
  • Supports multiple file formats: output file formats include BIF, TIF and DICOM

VENTANA DP 200 slide scanner




Scopio Labs
  • Scopio harnesses the power of computational photography and AI to image and analyze the morphology of cells at a large scale, expediting access to life saving treatments and improved patient outcomes


X100HT
  • Capacity: 30 slide capacity (3 cassettes x 10 slides); up to 40 slides/hour for 200 WBC differential
  • Automated oil drop and coverslip
  • View in full context or zoom in at 100x
  • AI driven WBC preclassification, platelet pre-estimation and seamless sharing of results
  • Collaborate and consult through telehematology with sample review possible from any location over the secure hospital network


X100
  • Capacity: 3 slide tray; up to 15 slides/hour for 200 WBC differential
  • Manual oil drop and coverslip
  • View in full context or zoom in at 100x
  • AI driven WBC preclassification, platelet pre-estimation and seamless sharing of results
  • Collaborate and consult through telehematology with sample review possible from any location over the secure hospital network


Visiopharm
  • Visiopharm® is a world leader in AI driven digital precision pathology software
  • Visiopharm's pioneering image analysis tools support thousands of scientists, pathologists and image analysis experts in both academic institutions and the biopharmaceutical industry


Oncotopix Scan Nanozoomer S360
  • Automatic system calibration
  • Capacity: 360 standard slides
  • Scanning speed: ~30s (20x and 40x, 15 x 15 mm)
  • Z stacking scanning of cytology and thick histology slides
  • Multilevel scanning of whole slides


Oncotopix Scan Nanozoomer SQ
  • Capacity: 26 mm x 76 mm, 1 slide
  • Compact size
  • Scanning speed: ~150s (20x) and 275s (40x) (15 x 15 mm)
  • Z stacking scanning of cytology and thick histology slides
  • Barcode support included


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