Bone & joints


Juvenile rheumatoid arthritis

Topic Completed: 1 May 2013

Minor changes: 30 July 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Juvenile rheumatoid arthritis [title] "loattrfree full text"[sb]

Vijay Shankar, M.D.
Page views in 2020: 1,036
Page views in 2021 to date: 968
Cite this page: Shankar V. Juvenile rheumatoid arthritis. website. Accessed October 25th, 2021.
Definition / general
  • Common connective tissue disease in children age 15 years or less - most common chronic rheumatic illness in children (Dermatology Online Journal 2001;7:19)
  • Worldwide incidence varies from 0.008 to 0.226 per 1,000 children
  • Knees, wrists, elbows, ankles
  • Pathogenesis: oligoarthritis and polyarthritis group are T helper 1 cell mediated disorders; precise mechanisms are unclear but proinflammatory cytokines are responsible for part of clinical symptoms (Korean J Pediatr 2010;53:921)
Diagrams / tables

Images hosted on other servers:

Cytokine signaling pathways

Clinical features
  • 65% male
  • Either oligoarticular ( > 5 joints), polyarticular (5 or more joints) or systemic
  • Compared to classic rheumatoid arthritis, oligoarthritis is more common; systemic large joints are affected more than small joints
  • Associated with HLA-DRB1, infections by mycobacteria, bacteria, viruses
  • 70% recover, 10% have residual severe joint deformities
  • Usually seronegative for rheumatoid factor
  • Symptoms: systemic onset with fever, rash, hepatosplenomegaly, serositis; also warm and swollen joints; pericarditis, myocarditis, pulmonary fibrosis, glomerulonephritis, uveitis, growth retardation
Case reports
Clinical images

Images hosted on other servers:

Various images

Swelling and flexion contracture

Polyarticular disease

Systemic onset disease

Microscopic (histologic) description
  • Similar morphologic changes as adult rheumatoid arthritis but less severe
Microscopic (histologic) images

Images hosted on other servers:

Various images

Back to top
Image 01 Image 02