Bone & joints

Other nonneoplastic

Synovial lipomatosis

Topic Completed: 1 June 2013

Minor changes: 30 July 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Synovial lipomatosis

Vijay Shankar, M.D.
Page views in 2020: 2,287
Page views in 2021 to date: 2,435
Cite this page: Shankar V. Synovial lipomatosis. website. Accessed October 25th, 2021.
Definition / general
  • Also called Hoffa disease, villous lipomatous proliferation of synovium, lipoma arborescens
  • Pseudotumor of synovium with distinct histomorphology, possibly due to inappropriate fat deposition and degenerative articular diseases of joints (J Lab Physicians 2011;3:84)
Clinical features
  • Rare; usually knee but may occur in any joint
  • Unknown etiology
  • Males commonly affected with pain and swelling of joint
  • Arthroscopy and excision
Gross description
  • Enlargement of infrapatellar fat pad with pain in anterior compartment of knee; synovium is papillary, yellow and fatty
Microscopic (histologic) description
  • Synovial hyperplasia with unremarkable fat extending to synovial lining; occasional chronic inflammatory infiltrate
Microscopic (histologic) images

Images hosted on other servers:

Villi-like structures

Papillary architecture

Mature adipocytes

Focal hyperplasia

Few mature lipocytes

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