Kidney nontumor / medical renal

Monoclonal gammopathy of renal significance (MGRS) / paraprotein-related kidney disease

Heavy chain deposition disease

Last author update: 1 September 2012
Last staff update: 10 September 2021

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PubMed Search: Heavy chain deposition disease [title] kidney pathology

Nikhil Sangle, M.D.
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Cite this page: Sangle N. Heavy chain deposition disease. website. Accessed February 22nd, 2024.
Definition / general
  • Lymphoplasmacytic neoplasm that produces an abnormally truncated immunoglobulin heavy chain protein that lacks associated light chains (eMedicine: Gamma Heavy Chain Disease [Accessed 17 January 2018])
  • Less common than light chain deposition disease
  • May have milder hematological disorders than in light chain deposition disease (Clin Nephrol 2009;71:9)
  • Associated with various lymphoproliferative disorders, but usually has features overlapping with cases previously reported as "vaguely nodular, polymorphous" lymphoplasmacytic lymphoma (Am J Surg Pathol 2012;36:534)
Case reports
  • 51 year old man with linear deposits of gamma 4 heavy chains along glomerular, tubular and vascular basement membrane and in mesangial regions (Mod Pathol 1994;7:874)
  • 68 year old woman with gamma 1 heavy chain disease (Intern Med 2010;49:1411)
  • Monotypic mu heavy chain mesangial deposits causing nodular glomerulosclerosis in woman without evident hematopoietic malignancy (Hum Pathol 2000;31:122)
  • Follow up biopsy post chemotherapy showed remarkable diminution of both nodular glomerular lesions and IgG heavy chain deposits (Clin Nephrol 2008;69:383)
Microscopic (histologic) images

Images hosted on other servers:

Various images

Immunofluorescence description
  • IgG heavy chains along glomerular, tubular and vascular basement membranes and in mesangium
  • No light chain deposition
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