Kidney nontumor

Tubulointerstitial disease



Topic Completed: 3 December 2012

Minor changes: 13 September 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Nephrocalcinosis [title]

Nikhil Sangle, M.D.
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Cite this page: Sangle N. Nephrocalcinosis. website. Accessed December 6th, 2021.
Definition / general
  • Conditions associated with chronic hypercalcemia, including primary hyperparathyroidism, myeloma or other malignancy; also distal renal tubular acidosis, hypercalciuria due to chronic furosemide use in premature infants (Hum Pathol 2000;31:1363), milk alkali syndrome, oral sodium phosphate as bowel preparation (Hum Pathol 2004;35:675), sarcoidosis, vitamin D intoxication
  • Reduce urinary saturation of calcium by increasing fluid intake, crystallization inhibitors, disease-specific medication, (Kidney Int 2011;80:1278)
Microscopic (histologic) description
  • Diffuse tubular injury with atrophy, interstitial fibrosis and abundant tubular deposition of calcium phosphate
  • Over time, glomerulosclerosis and vascular disease
Microscopic (histologic) images

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