Kidney nontumor / medical renal
Tubulointerstitial disease
Immunologic
Sarcoidosis
Author: Nikhil Sangle, M.D.
Last author update: 3 December 2012
Last staff update: 20 September 2023
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PubMed Search: Sarcoidosis kidney
Table of Contents
Definition / general | Case reports | Treatment | Microscopic (histologic) description | Microscopic (histologic) images | Immunofluorescence description | Electron microscopy descriptionCite this page: Sangle N. Sarcoidosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/kidneysarcoidosis.html. Accessed April 25th, 2024.
Definition / general
- Often white men lacking skin, eye or lung involvement
- Often hypercalcemia and fever at presentation of renal sarcoidosis (Medicine (Baltimore) 2009;88:98)
- Renal failure in < 3% (Rev Pneumol Clin 2011;67:342)
- Cases with renal involvement difficult to diagnose on renal biopsy due to focal nature (Int J Nephrol Renovasc Dis 2011;4:131)
Case reports
- 19 year old woman who died of rapidly progressive renal and respiratory failure (Arch Pathol Lab Med 1989;113:1295)
- With nephrotic syndrome resistant to steroids and immunosuppression (Arch Pathol Lab Med 1978;102:572)
Treatment
- Prednisone for renal insufficiency (Arch Pathol Lab Med 1990;114:488)
- Renal transplantation, recurrence in 27% (Clin J Am Soc Nephrol 2010;5:2101)
Microscopic (histologic) description
- Diagnosis of exclusion
- Interstitial noncaseating granulomatous nephritis, nephrocalcinosis, often segmental thickening and wrinkling of glomerular capillary walls
- Granulomas look fibrotic with minimal or no lymphocytic cuffing (naked nuclei)
Microscopic (histologic) images
Images hosted on other servers:
Various images
Granulomatous interstitial nephritis
nonspecific features,
which is common
Recurrence after renal transplant
Immunofluorescence description
- No specific findings
Electron microscopy description
- Numerous single and coalescent calcific microspherules within basement membrane, paramesangial zone and mesangium
