Kidney tumor

Adult renal cell carcinoma - common

Papillary solid growth

Last author update: 1 February 2018
Last staff update: 20 December 2023 (update in progress)

Copyright: 2002-2024,, Inc.

PubMed Search: Solid papillary renal cell carcinoma (Review[ptyp] AND "loattrfree full text"[sb])

See Also: Papillary type, renal cell carcinoma, Type 1, Type 2

Nicole K. Andeen, M.D.
Maria Tretiakova, M.D., Ph.D.
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Cite this page: Andeen NK, Tretiakova M. Papillary solid growth. website. Accessed April 14th, 2024.
Definition / general
Essential features
  • Similar to type 1 PRCC by morphology, immunohistochemistry and cytogenetics but lacks true papillae
  • M:F = 1.7:1
  • Comprises less than 3% of all PRCCs
  • Kidney
Case reports
Gross description
Microscopic (histologic) description
  • Solid sheets of cells, often with distinct micronodules resembling abortive papillae or glomeruloid bodies, surrounded by a pseudocapsule (Histopathology 2013;62:941)
  • Resembles type 1 PRCC immunophenotypically and genetically but lacks true papillae containing fibrovascular cores (Am J Surg Pathol 1997;21:1203)
  • Cells have scant to abundant clear, basophilic or eosinophilic cytoplasm
  • Nuclei may be low or high grade, may have nucleoli or nuclear grooves
  • May have compact areas of low grade spindle cells lining thin, angulated tubules resembling mucinous tubular and spindle cell carcinoma but no mucinous stroma (Am J Surg Pathol 2008;32:1353)
  • May have foamy macrophages, psammoma bodies (Histopathology 2013;62:941)
Microscopic (histologic) images

Contributed by Nicole K. Andeen, M.D. and Maria Tretiakova, M.D., Ph.D.

Solid PRCC

Positive stains
Negative stains
Molecular / cytogenetics description
  • Trisomy 7 and 17, similar to type 1 PRCC
Differential diagnosis
Board review style question #1
Which of the following statements about papillary renal cell carcinoma, solid growth pattern is true?

  1. Has a poor clinical outcome
  2. Is a type 2 PRCC with solid growth pattern
  3. Is immunohistochemically and cytogenetically distinct from both type 1 and type 2 PRCC
  4. Shares morphologic, immunohistochemical and cytogenetic features with type 1 PRCC but lacks true papillae
Board review style answer #1
D. Shares morphologic, immunohistochemical and cytogenetic features with type 1 PRCC but lacks true papillae

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