Kidney tumor

Benign adult tumors

Oncocytosis



Topic Completed: 1 February 2012

Minor changes: 26 February 2021

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: Oncocytosis kidney

Mandolin S. Ziadie, M.D.
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Cite this page: Ziadie MS. Oncocytosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/kidneytumoroncocytosis.html. Accessed December 8th, 2021.
Definition / general
  • Rare diffuse renal involvement by numerous oncocytic lesions without necrosis
  • Often associated with at least 1 dominant nodule (2 - 10 cm), usually an oncocytoma, chromophobe carcinoma or hybrid; recent study suggests neoplasms are distinct from oncocytoma or chromophobe carcinoma (Am J Surg Pathol 2010;34:620)
  • 43% bilateral; may be hemorrhagic
  • Associated with chronic kidney disease (J Urol 2011;185:795)
Pathophysiology
  • The coexistence of oncocytosis and chromophobe renal carcinoma suggests that these two lesions are related and part of a spectrum of oncocytic disease
Case reports
Gross description
  • Well circumscribed, unencapsulated and solid lesion with a homogenous mahogany or yellowish brown cut surface
Gross images

AFIP images

Kidney contained nine discrete tumors

Microscopic (histologic) description
  • Multiple oncocytic nodules, often hybrid nodules with chromophobe carcinoma
  • An interstitial pattern (oncocytes infiltrate between benign glomeruli and tubules), diffuse oncocytic change in nonneoplastic tubules and benign oncocytic cortical cysts may also be present
Additional references
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